Včelařská konference

Citace:Amitraz is not mutagenic, however, it forms a mutagenic (in vitro evidence only) and
carcinogenic metabolite, 2,4 dimethylaniline. The tumor response for 2,4
dimethylaniline is different from amitraz in that neither liver nor lung tumors are
observed.

Although potential carcinogenicity cannot be totally dismissed because of the
mutagenic/carcinogenic metabolite, the tumor data for amitraz are not very compelling for the
reasons stated above. Thus, the Agency is regulating this chemical on the basis of an acute
endpoint which is considered protective for all effects, regardless of exposure duration.

Viz: http://archive.epa.gov/pesticides/reregistration/web/pdf/amitraz_tred.pdf

Citace:
Amitraz may pose a concern for potential carcinogenic risks to certain categories of
workers. Amitraz is classified as a Group C (possible human) carcinogen, based on findings
of combined liver adenomas/carcinomas in female B6C3F1 mice. Estimates of human risk
may be calculated from the unit risk, Q *, which is 5 x 10 (mg/kg/day) , based on findings 1
-2 -1
of combined hepatocellular adenomas and carcinomas in female mice. Additionally, there
may also be a potential for a developmental, neurological and/or reproductive risk, based on
available toxicology information. These issues will be assessed after a confirmatory
combined developmental/neurological/reproductive study in rats is submitted and evaluated.

Viz. http://archive.epa.gov/pesticides/reregistration/web/pdf/0234red.pdf

http://sitem.herts.ac.uk/aeru/ppdb/en/Reports/30.htm#trans